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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 Dec 6;134(1):46–55. doi: 10.1016/j.jaci.2013.08.053

Table I.

Summary statistics of the 3 SNPs at P < 5×10−8.

Marker MAF β S.E. P I2 HetP
rs3751972[C] at 17q11.2 (LYRM9) 0.25 0.086 0.014 1.97×10−10 27.4 0.161
rs944722[C] at 17q11.2-q12 (NOS2) 0.38 −0.073 0.012 1.28×10−09 37.8 0.075
rs8069176[A] at 17q12-q21 (nearest genes ZPBP2-GSDMB) 0.43 −0.066 0.012 1.88×10−08 0.0 0.668

Single nucleotide polymorphisms (SNPs) markers are identified according to their standard rs numbers (NCBI build 36). Independent SNPs with a genome-wide significant effect on FeNO levels in children are shown (P < 5×10−8). The total sample includes data of 14 independent GWA datasets (N = 8,858). MAF, minor allele frequency; S.E., standard error. β reflects differences in natural log-transformed FeNO per minor allele. P values are obtained from linear regression of each SNP against natural log-transformed FeNO adjusted for sex and age at time of measurement (fixed-effect additive genetic model). Derived inconsistency statistic I2 and HetP values reflect heterogeneity across studies with the use of Cochran's Q tests.