Table III.
Association of known physician-diagnosed asthma loci, from a previous GWA study5 with childhood FeNO.
| Physician-diagnosed asthma5 | ||||||
|---|---|---|---|---|---|---|
| Marker | MAF | β | S.E. | P | I2 | HetP |
| rs2305480[A] decreasing risk-allele at 17q12 (GSDMB) | 0.42 | −0.065 | 0.012 | 2.83×10−08 | 0.0 | 0.731 |
| rs3894194[A] increasing risk-allele at 17q21.1 (GSDMA) | 0.47 | 0.048 | 0.012 | 6.35×10−05 | 9.5 | 0.349 |
| rs744910[A] decreasing risk-allele at 15q22.33 (SMAD3) | 0.49 | −0.039 | 0.012 | 8.41×10−04 | 0.0 | 0.491 |
| rs1295686[T] increasing risk-allele at 5q31 (IL13) | 0.27 | 0.044 | 0.014 | 1.25×10−03 | 4.6 | 0.401 |
| rs1342326[C] increasing risk-allele at 9p24.1 (IL33) | 0.17 | 0.025 | 0.016 | 0.119 | 0.0 | 0.515 |
| rs9273349[T] decreasing risk-allele at 6p21.3 (HLA-DQ) | 0.37 | −0.022 | 0.022 | 0.310 | 0.0 | 0.802 |
| rs11071559[T] decreasing risk-allele at 15q22.2 (RORA) | 0.14 | −0.014 | 0.017 | 0.415 | 0.0 | 0.651 |
| rs3771166[A] decreasing risk-allele at 2q12 (IL18R1) | 0.35 | −0.009 | 0.012 | 0.463 | 7.4 | 0.371 |
| rs2284033[A] decreasing risk-allele at 22q13.1 (IL2RB) | 0.42 | 0.005 | 0.012 | 0.705 | 0.0 | 0.633 |
| rs2073643[T] increasing risk-allele at 5q23.3 (SLC22A5) | 0.47 | 0.000 | 0.012 | 0.993 | 0.0 | 0.590 |
Single nucleotide polymorphisms (SNPs) markers are identified according to their standard rs numbers (NCBI build 36). We explored whether common genetic variants known to be related with physician-diagnosed asthma5 were associated with childhood FeNO. The total sample includes data of 14 independent GWA datasets (N = 8,858). MAF, minor allele frequency; S.E., standard error. β reflects differences in natural log-transformed FeNO per minor allele. P values are obtained from linear regression of each SNP against natural log-transformed FeNO adjusted for sex and age at time of measurement (fixed-effect additive genetic model). Derived inconsistency statistic I2 and HetP values reflect heterogeneity across studies with the use of Cochran's Q tests.