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. 2014 Oct 28;12:22. doi: 10.1186/1477-9560-12-22

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© Harder; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of rivaroxaban 5 mg and 30 mg, and placebo, on thrombin generation. (A) ETP peak after activation by collagen (5 μg/ml), (B) ETP peak after activation by tissue factor (1.4 nmol). Data are mean relative change from baseline ± standard deviation. The difference between treatments was assessed in this study using the area under the time–effect profile curve; both rivaroxaban doses were significantly different from placebo, but not significantly different from each other. Reproduced with permission from Graff J et al.[28]. ETP, endogenous thrombin potential.