Table 4.
Summary of pharmacokinetic and pharmacodynamic drug interactions with rivaroxaban [12, 13, 25, 47–50]
| Medication class and drug name | Extent of drug–drug interaction with rivaroxaban | ||
|---|---|---|---|
| None/not clinically relevant (routine co-administration possible) | Moderate clinical relevance (co-administer with caution) | High clinical relevance (avoid co-administration) | |
| HIV protease inhibitors | |||
| Ritonavir | X | ||
| Azole-antimycotics | |||
| Ketoconazole | X | ||
| Fluconazole | X | ||
| Antibiotics | |||
| Clarithromycin | X | ||
| Erythromycin | X | ||
| Rifampicin | X | ||
| Anticoagulants | |||
| Enoxaparin | X | ||
| Warfarin | Xa | ||
| NSAIDs and platelet inhibitors | |||
| Naproxen | X | ||
| Clopidogrel | X | ||
| Aspirin | X | ||
| Cardiac medications | |||
| Digoxin | X | ||
| Atorvastatin | X | ||
| Dronedarone | Xb | ||
| Stomach acid regulators | |||
| Ranitidine | X | ||
| Aluminium-magnesium hydroxide (antacid) | X | ||
| Sedatives | |||
| Midazolam | X | ||
| Antidepressants | |||
| St John’s wort | X | ||
| Anticonvulsants | |||
| Phenytoin | X | ||
| Carbamazepine | X | ||
| Phenobarbital | X | ||
aExcept when switching; bbased on a lack of clinical information.
HIV, human immunodeficiency virus; NSAID, non-steroidal anti-inflammatory drug.