Table 1. Demographic and clinical characteristics of CADASIL in patients with the R544C mutation.
| No stroke (n = 19) | Stroke (n = 32) | p value | |
|---|---|---|---|
| Demographics | |||
| Age, y (SD) | 59.8±11.7 | 64.1±11.4 | 0.254 |
| male, female | 8, 11 | 19, 13 | 0.232 |
| Education, y (SD) | 9.1±4.9 | 7.4±5.8 | 0.355 |
| Medical history | |||
| Hypertension | 4 (21.0) | 22 (68.7) | 0.001 |
| Diabetes Mellitus | 2 (10.5) | 4 (11.4) | 1.000 |
| Hypercholesterolemia | 1 (5.3) | 7 (21.9) | 0.231 |
| Ever-smoking | 5 (26.3) | 10 (31.3) | 0.688 |
| Ischemic heart disease | 1 (5.3) | 3 (9.4) | 1.000 |
| MRI characteristics | |||
| Presence of lacunes | 8 (42.1) | 25 (78.1) | 0.009 |
| Number of lacunes | 2.5±5.6 | 4.5±6.4 | 0.016 |
| Presence of CMBs | 8 (42.1) | 20 (62.5) | 0.157 |
| Number of CMBs | 1.4±2.5 | 9.9±16.1 | 0.010 |
| nWMHs | 2.3±2.0 | 3.1±1.5 | 0.037 |
Data are mean ± SD or n (%) values.
CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
nWMHs normalized White Matter Hyperintensities.