Table 3.

Multivariable logistic regression models for the development of post-operative atrial fibrillation in the discovery cohort

	Combined clinical/genetic model			Clinical-only model
Variable	β (SE)	OR (95% CI)	P value	β (SE)	OR (95% CI)	P value
Age (per 5 years)	0.2435 (0.0105)	1.28 (1.25 to 1.3)	<0.0001	0.2355 (0.0103)	1.27 (1.24 to 1.29)	<0.0001
PR interval (per 20 ms)	0.154 (0.0044)	1.36 (1.35 to 1.37)	0.0005	0.292 (0.0042)	1.34 (1.33 to 1.35)	0.0006
Previous AF	1.9475 (0.3449)	7.01 (3.57 to 13.8)	<0.0001	1.8653 (0.3335)	6.46 (3.36 to 12.4)	<0.0001
Hypertension	0.6006 (0.3013)	1.82 (1.01 to 3.29)	0.05	0.5527 (0.2983)	1.74 (0.97 to 3.12)	0.06
Diabetes	0.1283 (0.2243)	1.14 (0.73 to 1.76)	0.57	0.1552 (0.2162)	1.17 (0.76 to 1.78)	0.47
LVEF<40%	0.356 (0.2648)	1.43 (0.85 to 2.4)	0.18	0.3806 (0.2605)	1.46 (0.88 to 2.44)	0.14
Pre-op beta blocker	−0.0148 (0.2258)	0.99 (0.63 to 1.53)	0.95	−0.0749 (0.2196)	0.93 (0.6 to 1.43)	0.73
Post-op beta blocker	−0.2621 (0.3163)	0.77 (0.41 to 1.43)	0.41	−0.1911 (0.3084)	0.83 (0.45 to 1.51)	0.54
rs13376333 (T)	−0.9951 (0.8129)	0.37 (0.08 to 1.82)	0.22
rs6666258 (C)	1.3839 (0.797)	3.99 (0.84 to 19)	0.08
rs3903239 (A)	−0.158 (0.1631)	0.85 (0.62 to 1.18)	0.33
rs2200733 (T)	0.2145 (0.2398)	1.24 (0.77 to 1.98)	0.37
rs3807989 (A)	0.0531 (0.1589)	1.05 (0.77 to 1.44)	0.74
rs10821415 (A)	0.1051 (0.1482)	1.11 (0.83 to 1.49)	0.48
rs10824026 (G)	−0.2249 (0.1959)	0.8 (0.54 to 1.17)	0.25
rs1152591 (A)	0.212 (0.1506)	1.24 (0.92 to 1.66)	0.16
rs2106261 (A)	−0.2831 (0.333)	0.75 (0.39 to 1.45)	0.4
rs7193343 (C)	−0.1107 (0.3475)	0.9 (0.45 to 1.77)	0.75

SE: standard error. OR: odds ratio. CI: confidence interval. ms: milliseconds. AF: atrial fibrillation. LVEF: left ventricular ejection fraction