. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Cancer Causes Control. 2015 Jan 25;26(3):467–473. doi: 10.1007/s10552-015-0526-3

Table 4.

Genotype-polyp associations from trait-specific allele scores, Group Health, 1998–2007

Cholesterol measurement	Unit change for OR (scaled)^a	Advanced adenoma cases (N=139) vs. controls (N=754)		Non-advanced adenoma cases(N=518) vs. controls (N=754)		Non-adenomatous polyp cases (N=380) vs. controls (N=754)
Cholesterol measurement	Unit change for OR (scaled)^a	OR^b (95% CI)	P	OR^b (95% CI)	P	OR^b (95% CI)	P
LDL allele score	+20 mg/dL	1.17 (0.78, 1.75)	0.46	0.99 (0.77, 1.27)	0.95	1.13 (0.86, 1.49)	0.40
HDL allele score	−10 mg/dL	0.95 (0.60, 1.48)	0.81	1.05 (0.79, 1.39)	0.76	1.03 (0.75, 1.41)	0.87
TG allele score	+40 mg/dL	1.12 (0.91, 1.38)	0.30	1.09 (0.95, 1.24)	0.21	1.07 (0.92, 1.23)	0.39
TC allele score	+20 mg/dL	0.99 (0.71, 1.38)	0.94	1.02 (0.83, 1.26)	0.84	1.08 (0.86, 1.37)	0.51

+8.7 units for LDL allele score, +11.1 units for HDL allele score, +4.1 units for TG allele score, +8.0 units for TC allele score.

OR is adjusted for age at colonoscopy, sex, race, and data-collection period.

Abbreviations: CI, confidence interval; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; OR, odds ratio; TC, total cholesterol; TG, triglycerides.