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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Mol Med (Berl). 2015 Jan 23;93(3):253–262. doi: 10.1007/s00109-015-1254-6

Table 1.

Mitophagy regulators and cardiac phenotypes

Model Mitophagy Phenotype Ref
Parkin−/− Decreased Increased sensitivity to MI and doxorubicin exposure, accumulation of dysfunctional mitochondria, and oxidative damage with age, reduced life span [6, 8, 78]
Parkin TG Increased Increased life span, preserved cardiac function with aging [6, 97]
PINK1−/− Not assessed Mitochondrial dysfunction, cardiomyopathy, increased sensitivity to I/R [7, 90]
BNIP3−/− Not assessed Decreased apoptosis and cardiac remodeling in response to I/R [93]
BNIP3 TG Not assessed Increased sensitivity to MI, increased apoptosis [93]
NIX−/− Not assessed Decreased cardiac remodeling and preserved cardiac function in response to pressure overload [92]
NIX TG Not assessed Ventricular dilation, reduced cardiac function [95]
BNIP3−/−
Nix−/−
Not assessed Accumulation of dysfunctional mitochondria, development of cardiac hypertrophy, decreased cardiac function [82]