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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Surv Ophthalmol. 2014 Dec 18;60(2):153–165. doi: 10.1016/j.survophthal.2014.11.004

Table 2. Cases of Lymphoma with Optic Nerve Involvement and Central Nervous System Disease.

Year/
Author		 Age/
Sex		 Diagnosis Initial Visual
Symptom		 Timing of
visual
Symptom		 Fundus Findings Imaging Lumbar
Puncture		 Type of Biopsy /
ON location		 Treatment Outcome+
B-cell lymphomas
Bullock, 1979 75 M Poorly differentiated NHL Decreased VA OD, Diplopia 1 mo after chemotherapy initiation normal CT (-) Orbital xray (+) 7 mononuclear cells, low glucose ON at autopsy/ INT XRT Death, 31d
Guyer, 1990 57 F Mixed cell NHL Diplopia 5 mo after diagnosis, 1 mos after CNS involvement CRAO CT (-) Carotid dopplar (-) Atypical lymphocytes, increased intracranial pressure ON at autopsy/ LPM IT, XRT Death, 8wk
Zaman, 1993 42 F Centroblastic NHL Decreased VA OU 6 mo after chemotherapy ON pallor, VF defect CT (+), MRI (+) wnl No biopsy done XRT n/a
Saatci, 1999 14 M Diffuse Large B-cell NHL Decreased VA OS 5 mo after chemotherapy CRAO, CRVO MRI (+) periventricular tumor infiltration High protein No biopsy done IVc, IVs, IT XRT Death, 24mo
Lee, 2002 56 M Large B-cell NHL Decreased VA OS, CN5 palsy 4 mo after diagnosis ON edema, RV engorgement, 4 quad IRH MRI (+) wnl ON at autopsy/ LPM IVs, XRT Death, 3 weeks
El Kettani, 2006 75 M Large B-cell NHL Decreased VA OU, CN5 palsy 8 years after diagnosis B ON edema CT (+) Atypical Lymphocytes No biopsy done IVc, IVs, IT Death, 2 mo
Zelefsky, 2008 72 F Diffuse small B-cell Decreased VA OD, VF defect Presenting symptom ON pallor MRI (+) chiasm and tract n/a ON/ INT and LPM IVc, PO Death, 3mo
Matsuyama, 2013 84F Diffuse large B-cell NHL Decreased VA OU Presenting symptom n/a MRI (+) suprasellar tumor n/a fronto-temporal craniotomy PO n/a
Matsuyama, 2013 67M Malignant Lymphoma Decreased VA OD Presenting symptom n/a MRI (+) chiasm n/a fronto-temporal craniotomy IVc Death, 39mo
Case 2, 2014 25 F Burkitt Lymphoma Decreased VA OS After 6 cycles of chemotherapy Normal MRI (+) Trigeminal nerve involvement wnl ON/ LPM XRT Hospice care, 2mo
T-cell lymphomas
Kitzmann, 2008 39 M T-cell NHL Decreased VA OU After 2 cycles of chemotherapy ON edema, flame hemorrhages, vein dilation, VF defects MRI (+) n/a ON/ INT IVc, XRT Death, 3mo
Coleman, 2013 41M Anaplastic Large T-cell NHL Decreased VA OD, eye pain Presenting symptom n/a * asymmetric proptosis, ophthalmoplegia, chemosis MRI (+) optic tract, chiasm, vasogenic edema of frontal lobe n/a total ethmoidectomy, maxillary antrostomy IVc, XRT, PO n/a

M=male, F=female, NHL = Non Hodgkins lymphoma, OD=right eye, OS=left eye, OU=both eyes, CN=cranial nerve, VF= visual field, mo = months, CNS=central nervous system, CRAO = central retinal artery occlusion, CRVO = central retinal vein occlusion, ON = Optic Nerve, , n/a = information not available, (-) = negative findings, (+) = positive findings, wnl = within normal limits, INT = intrinsic, LPM = leptomeningeal, IVc = intravenous chemotherapy IVs = intravenous steroids, IT = intrathecal chemotherapy, PO = oral steroids, XRT = radiation therapy,

*

timing of death is with respect to onset of visual symptoms