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. Author manuscript; available in PMC: 2016 Mar 7.
Published in final edited form as: Org Biomol Chem. 2015 Mar 7;13(9):2726–2744. doi: 10.1039/c4ob02489c

Table 4.

Intramolecular Friedel-Crafts Alkylation

graphic file with name nihms657430t4.jpg
Reactant n R1 R2 Product % Yield
9a 1 H H 11a dec.
9b 1 OCH3 H 11b 98*
9c 1 H OCH3 11c dec.
9d 1 OCH3 OCH3 11d 97*
9e 1 CH3 H 11e 76*
10a 2 H H 12a 63
10b 2 OCH3 H 12b 88*
10c 2 H OCH3 12c dec.
10d 2 OCH3 OCH3 12d 84*
10e 2 CH3 H 12e 70*
*

Product was obtained as a mixture of C-2 epimers; dec=decomposed