Table 5.
Over-representation of the cell types for the alcohol-responsive mRNAs in synaptoneurosomes (SN) and total homogenates (TH)
| Data set | Microglia | P-value | Astrocytes | P-value | Neuron | P-value | Oligodendrocytes | P-value | Glutamate | P-value | GABA | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SN enriched | 28 | 5.02E − 04 | 250 | 1.03E − 27 | 39 | 8.68E − 01 | 45 | 6.10E − 05 | 102 | 1.13E − 03 | 152 | 4.71E − 22 |
| TH enriched | 15 | 5.97E − 01 | 43 | 1.00E+00 | 101 | 2.55E − 13 | 24 | 7.34E − 01 | 166 | 1.71E − 20 | 74 | 4.88E − 01 |
| Alcohol’s effect on SN | 25 | 5.40E − 02 | 115 | 5.33E − 05 | 55 | 5.87E − 01 | 19 | 9.94E − 01 | 99 | 4.10E − 01 | 99 | 1.30E − 01 |
| Alcohol’s effect on TH | 7 | 3.94E − 01 | 26 | 4.95E − 01 | 18 | 4.92E − 01 | 7 | 8.60E − 01 | 32 | 4.53E − 01 | 27 | 6.46E − 01 |
| Alcohol-responsive upregulated SN | 20 | 5.81E − 03 | 91 | 2.51E − 09 | 8 | 1.00E+00 | 14 | 8.94E − 01 | 60 | 4.36E − 01 | 70 | 1.27E − 02 |
| Alcohol-responsive downregulated SN | 5 | 8.52E − 01 | 24 | 9.52E − 01 | 47 | 5.12E − 07 | 5 | 9.95E − 01 | 39 | 4.88E − 01 | 29 | 8.94E − 1 |
The number of overlapping mRNAs and over-representation P-values are shown for microglia, astrocyte, neuron, oligodendrocyte, glutamate and GABA mRNA lists. The significant values (P < 0.05) are bolded. Fold changes above 10% were used for the SN- and TH-enriched lists.