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. 2015 Jan 20;33(7):740–748. doi: 10.1200/JCO.2014.57.6801

Table 2.

Descriptive Statistics for PRO Measures at Each Time Point by Treatment Arm

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Time Point and Subscale Score Range* RR
 MR
 Difference in Mean Score P (t test)
No. of Patients Mean Score SD of Score No. of Patients Mean Score SD of Score
Baseline
    IES-R 0-88 128 15.90 14.67 124 15.24 13.29 −0.66 .716
    FACT-G 0-108 128 87.81 13.18 124 89.65 12.73 1.84 .289
    IRW 0-36 127 11.66 7.58 125 10.41 6.71 −1.25 .194
    HADS-Anxiety 0-21 126 4.27 3.72 123 4.31 3.90 0.04 .876
    HADS-Depression 0-21 126 2.00 2.38 124 2.17 3.12 0.17 .612
    MAC 0-9 128 2.09 1.95 125 2.12 1.90 0.03 .836
3 months
    IES-R 0-88 105 14.65 12.37 109 14.83 13.95 0.18 .617
    FACT-G 0-108 106 90.45 12.49 108 88.77 13.85 −1.68 .549
    IRW 0-36 106 10.05 6.99 109 10.39 6.46 0.34 .819
    HADS-Anxiety 0-21 103 3.64 3.54 105 4.61 4.38 0.97 .276
    HADS-Depression 0-21 103 2.07 2.41 105 2.51 3.27 0.44 .481
    MAC 0-9 104 2.10 2.10 108 2.04 1.94 −0.06 .611
6 months
    IES-R 0-88 103 14.44 13.50 102 13.78 12.08 −0.66 .437
    FACT-G 0-108 100 88.86 13.77 101 88.43 15.06 −0.43 .970
    IRW 0-36 103 10.06 6.80 102 10.08 6.84 0.02 .703
    HADS-Anxiety 0-21 98 3.87 3.67 101 4.42 4.17 0.55 .469
    HADS-Depression 0-21 99 1.94 2.51 101 2.83 3.60 0.89 .076
    MAC 0-9 102 2.19 2.25 102 2.30 1.99 0.11 .840
12 months
    IES-R 0-88 102 13.33 13.26 100 13.01 12.39 −0.32 .567
    FACT-G 0-108 105 88.72 13.11 100 89.59 16.41 0.87 .525
    IRW 0-36 104 9.8 7.05 101 9.34 6.26 −0.46 .489
    HADS-Anxiety 0-21 99 4.03 3.79 99 3.95 4.13 −0.08 .493
    HADS-Depression 0-21 99 2.07 2.94 99 2.62 3.48 0.55 .279
    MAC 0-9 102 2.34 2.02 100 2.17 2.13 −0.17 .315
24 months
    IES-R 0-88 79 12.31 11.93 88 11.92 11.99 −0.39 .639
    FACT-G 0-108 81 89.37 13.28 88 89.84 14.48 0.47 .789
    IRW 0-36 80 9.09 6.65 85 8.77 6.02 −0.32 .644
    HADS-Anxiety 0-21 80 3.58 3.64 84 3.67 3.55 0.09 .969
    HADS-Depression 0-21 80 1.91 2.90 84 2.38 3.34 0.47 .288
    MAC 0-9 80 2.16 2.03 88 1.80 1.89 −0.36 .215
36 months
    IES-R 0-88 68 10.90 8.42 74 11.52 12.41 0.62 .995
    FACT-G 0-108 70 89.73 13.48 72 89.50 14.75 −0.23 .904
    IRW 0-36 68 10.16 6.45 73 9.09 6.45 −1.07 .287
    HADS-Anxiety 0-21 66 3.48 3.33 72 3.62 3.95 0.14 .974
    HADS-Depression 0-21 67 2.07 2.39 72 2.57 3.64 0.50 .398
    MAC 0-9 69 2.46 2.17 72 2.01 1.90 −0.45 .178
48 months
    IES-R 0-88 55 11.10 10.32 47 11.44 11.92 0.34 .973
    FACT-G 0-108 55 88.15 13.21 47 91.39 12.59 3.24 .248
    IRW 0-36 54 9.13 6.08 47 9.48 6.04 0.35 .823
    HADS-Anxiety 0-21 52 3.20 3.76 46 2.98 3.41 −0.22 .754
    HADS-Depression 0-21 53 1.73 2.22 46 2.00 3.13 0.27 .533
    MAC 0-9 55 1.85 1.91 47 2.17 2.07 0.32 .603
Rituximab failure
    IES-R 0-88 26 13.30 14.65 17 18.06 4.78 4.76 .508
    FACT-G 0-108 26 88.02 11.70 17 82.26 16.20 −5.76 .183
    IRW 0-36 27 9.44 6.20 17 18.35 16.50 8.91 .299
    HADS-Anxiety 0-21 27 4.11 3.52 17 11.24 8.22 7.13 .416
    HADS-Depression 0-21 27 2.17 2.66 17 4.88 5.48 2.71 .572
    MAC 0-9 26 1.69 2.09 17 3.76 5.33 2.07 .195

Abbreviations: FACT-G, Functional Assessment of Cancer Therapy–General; HADS, Hospital Anxiety and Depression Scale; IES-R, Impact of Event Scale–Revised; IRW, illness-related worry; MAC, Mental Adjustment to Cancer Scale; MR, maintenance rituximab; PRO, patient-reported outcome; RR, rituximab re-treatment; SD, standard deviation.

*

For FACT-G, higher score indicates better health-related quality of life. For all other PROs, higher scores indicate worse outcome (more symptoms).