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. 2015 Jan 20;33(7):740–748. doi: 10.1200/JCO.2014.57.6801

Table A4.

Change in PRO Measures Between Follow-Up and Baseline

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Time Point and PRO RR
 MR
 Difference in Mean Score P (t test)
No. of Patients Mean Score SD of Score No. of Patients Mean Score SD of Score
Between 3 months and baseline
    IES-R 105 −0.61 11.73 108 −1.42 10.81 −0.81 .600
    FACT-G 106 2.65 10.41 107 −0.53 7.03 −3.18 .010
    IRW 105 −1.63 5.98 109 −0.24 5.18 1.38 .072
    HADS-Anxiety 102 −0.62 2.95 103 0.09 2.85 0.71 .081
    HADS-Depression 102 0.04 2.03 104 0.21 1.70 0.17 .509
    MAC 104 −0.01 2.20 108 −0.19 1.93 −0.18 .537
Between 6 months and baseline
    IES-R 103 −1.67 13.26 101 −1.96 10.18 −0.28 .865
    FACT-G 100 1.04 12.82 100 −0.71 9.38 −1.76 .270
    IRW 102 −1.83 6.37 102 −0.44 5.12 1.39 .088
    HADS-Anxiety 98 −0.47 3.35 99 0.01 3.23 0.49 .301
    HADS-Depression 99 −0.03 2.82 100 0.57 2.55 0.60 .116
    MAC 102 0.14 2.26 102 0.24 1.99 0.10 .730
Between 12 months and baseline
    IES-R 102 −2.21 12.08 99 −3.01 11.17 −0.80 .627
    FACT-G 105 1.04 12.82 100 0.06 9.67 −0.99 .536
    IRW 103 −1.51 5.28 101 −1.20 5.34 0.31 .682
    HADS-Anxiety 98 −0.23 2.94 98 −0.20 3.71 0.03 .955
    HADS-Depression 98 0.02 2.69 98 0.39 3.40 0.37 .398
    MAC 102 0.32 2.12 100 −0.09 2.22 −0.41 .177
Between 24 months and baseline
    IES-R 79 −3.82 13.91 88 −3.94 11.81 −0.12 .952
    FACT-G 81 1.03 13.27 88 −0.54 11.48 −1.58 .409
    IRW 79 −2.42 7.13 85 −1.56 6.13 0.86 .409
    HADS-Anxiety 78 −0.71 3.44 82 −0.54 2.50 0.17 .725
    HADS-Depression 78 −0.17 2.77 83 0.16 2.65 0.32 .450
    MAC 80 0.10 2.07 88 −0.35 2.28 −0.45 .181
Between 36 months and baseline
    IES-R 68 −3.94 11.02 74 −3.94 12.21 0.00 1.000
    FACT-G 70 1.96 10.92 72 −1.75 10.62 −3.71 .042
    IRW 68 −1.37 5.15 73 −1.32 6.10 0.05 .956
    HADS-Anxiety 65 −0.46 3.04 70 −0.50 3.28 −0.05 .933
    HADS-Depression 66 0.10 2.67 71 0.73 2.62 0.63 .166
    MAC 69 0.45 2.35 72 −0.08 2.19 −0.53 .166
Between 48 months and baseline
    IES-R 55 −3.35 12.23 47 −5.67 12.24 −2.32 .342
    FACT-G 55 −0.18 10.80 47 0.54 8.81 0.72 .717
    IRW 54 −1.85 5.67 47 −1.76 5.77 0.09 .937
    HADS-Anxiety 52 −0.52 3.19 45 −0.82 3.27 −0.30 .649
    HADS-Depression 53 −0.23 2.23 45 0.17 2.38 0.40 .393
    MAC 55 −0.16 2.48 47 0.04 2.29 0.21 .666

NOTE. P values were from two independent sample t tests for comparison between treatment arms.

Abbreviations: FACT-G, Functional Assessment of Cancer Therapy–General; HADS, Hospital Anxiety and Depression Scale; IES-R, Impact of Event Scale–Revised; IRW, illness-related worry; MAC, Mental Adjustment to Cancer Scale; MR, maintenance rituximab; PRO, patient-reported outcome; RR, rituximab re-treatment; SD, standard deviation.