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. 2015 Feb 5;16(1):34. doi: 10.1186/s12864-014-1197-2

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© Rienksma et al.; licensee Biomed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Regulation of the cholesterol degradation pathway by IdeR, KstR and KstR2. Sequences similar to the IdeR binding boxes appear in the upstream regions of genes in the cholesterol degradation pathway in close proximity to (and sometimes overlapping with) the KstR and KstR2 binding regions. (A, B and C) Under either normal iron availability or lack of cholesterol either IdeR or KstR/KstR2 represses the expression of genes in this pathway. (D) Only under low iron availability (relieving IdeR repression) and in presence of cholesterol (relieving KstR and KstR2 repression), can the genes in the cholesterol degradation pathway be expressed.