Table 1.
Single-Nucleotide Polymorphisms (SNPs) Associated With Parasite Clearance Half-life
| Chromosome | SNP | Previous GWAS |
Replication GWAS |
Meta-analysis |
|||
|---|---|---|---|---|---|---|---|
| GEMMA P |
Random Forest Rank | GEMMA P |
Random Forest Rank | GEMMA P |
Random Forest Rank | ||
| 7 | MAL7:472852 | …a | …a | 5.17E-06 | 10 | …a | …a |
| 9 | MAL9:130454 | …a | …a | 6.91E-06 | >20 | …a | …a |
| 10 | MAL10:688956b | 3.41E-05 | 1 | 7.34E-02 | >20 | 7.27E-02 | >20 |
| 11 | MAL11:608589 | 2.76E-02 | >20 | 2.98E-04 | >20 | 6.39E-06 | >20 |
| 13 | MAL13:1718319b | 3.29E-03 | 2 | 8.68E-01 | >20 | 2.25E-01 | 4 |
| 13 | MAL13:1886271 | 1.35E-01 | >20 | 3.00E-03 | 1 | 5.47E-02 | 1 |
| 14 | MAL14:275834 | 7.50E-02 | >20 | …a | …a | 8.30E-06 | >20 |
| 14 | MAL14:3029267 | 1.13E-01 | >20 | 1.11E-03 | >20 | 8.10E-06 | >20 |
Significant associations are shown in bold.
Abbreviations: GEMMA, genome-wide mixed model association; GWAS, genome-wide association study.
a SNPs absent from analysis because of high levels of missing data or low minor-allele frequency
b SNPs identified in the previous GWAS.