Table 2.
Genes Associated With Parasite Clearance Half-life in Gene-Based Analysis
| Chromosome | Gene | Previous GWAS |
Replication GWAS |
Meta-analysis |
|||
|---|---|---|---|---|---|---|---|
| GEMMA P |
Random Forest Rank | GEMMA P |
Random Forest Rank | GEMMA P |
Random Forest Rank | ||
| 5 | PF3D7_0514600 | 9.77E-01 | >20 | 1.18E-05 | >20 | 1.27E-04 | >20 |
| 9 | PF3D7_0903100 | 7.61E-01 | >20 | 2.42E-05 | 16 | 2.05E-03 | >20 |
| 13 | PF3D7_1318100 | 3.22E-01 | 1 | 6.69E-01 | >20 | 5.40E-01 | 2 |
| 13 | PF3D7_1342300 | 1.39E-05 | >20 | 8.30E-01 | >20 | 3.05E-02 | >20 |
| 13 | PF3D7_1343700 | 2.47E-03 | 2 | 5.28E-10 | 1 | 5.46E-12 | 1 |
| 13 | PF3D7_1347200 | 2.45E-01 | >20 | 4.93E-03 | 2 | 4.10E-03 | 8 |
| 14 | PF3D7_1442600 | … | … | 3.55E-05 | 3 | 4.41E-06 | >20 |
Significant associations are shown in bold.
Abbreviations: GEMMA, genome-wide mixed model association; GWAS, genome-wide association study.
a Genes absent from analysis because of high levels of missing data.