Table 5.
Spearman Correlations Between Biomarker Levels at Baseline and Between Changes From Baseline to Week 4 in Biomarkers
| Biomarker | Correlation with LPS |
Correlation with sCD14 |
||||
|---|---|---|---|---|---|---|
| Subjects, No. | r | P Value | Subjects, No. | r | P Value | |
| Correlation between biomarkers at baseline | ||||||
| HLA-DR+CD38+ CD8+ T cells | 65 | −0.03 | .80 | 65 | −0.10 | .41 |
| Ki-67+ CD8+ T cells | 65 | 0.18 | .16 | 65 | 0.08 | .52 |
| IL-6 | 65 | 0.21 | .10 | 65 | 0.32 | .009 |
| LPS | 65 | 0.19 | .13 | |||
| CRP | 65 | 0.16 | .19 | 65 | 0.26 | .04 |
| sCD14 | 65 | 0.19 | .13 | |||
| d-dimer | 65 | 0.34 | .006 | 65 | 0.32 | .009 |
| sTNFrII | 65 | 0.02 | .86 | 65 | 0.10 | .44 |
| Correlation between changes in biomarkers from baseline to wk 4 | ||||||
| HLA-DR+CD38+ CD8+ T cells | 43 | 0.12 | .46 | 43 | −0.01 | .95 |
| Ki-67+ CD8+ T cells | 43 | 0.06 | .70 | 43 | 0.00 | .98 |
| IL-6 | 43 | −0.20 | .20 | 43 | 0.32 | .04 |
| LPS | 43 | −0.01 | .96 | |||
| CRP | 43 | −0.29 | .06 | 43 | 0.30 | .05 |
| sCD14 | 43 | −0.01 | .96 | |||
| d-dimer | 43 | −0.05 | .76 | 43 | 0.23 | .14 |
| sTNFrII | 42 | 0.02 | .90 | 42 | −0.11 | .47 |
Abbreviations: CRP, C-reactive protein; IL-6, interleukin 6; LPS, lipopolysaccharide; sCD14, soluble CD14; sTNFrII, soluble tumor necrosis factor α receptor II.