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Intracellular Ca2+ and frequency response in cardiomyocytes from WT and KD transgenic mice with or without paraquat (45 mg/kg, i.p.) or vehicle for 48 h. (A) Resting fura-2 fluorescence intensity (FFI). (B) Electrically stimulated rise in FFI (ΔFFI). (C) Peak fura-2 fluorescence intensity (peak FFI). (D) Single exponential intracellular Ca2+ decay. Mean ± SEM, n = 79–117 cells per group; *p < 0.05 versus WT group, #p < 0.05 versus WT-paraquat group.
