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. 2014 Oct 14;143(1):107–115. doi: 10.1093/toxsci/kfu216

FIG. 1.

FIG. 1.

Hepatoprotection of SolB against APAP-induced hepatotoxicity. SolB was gavaged to mice 7 times with an interval of 12 h, and a single dose of APAP (400 mg/kg, i.p.) was given 15 min after the seventh dose of SolB. Mice were sacrificed at 6 h after APAP treatment. A, Histopathological analysis of a representative mice liver samples following H&E staining. (1) Vehicle; (2) SolB (200 mg/kg); (3) APAP (400 mg/kg) + Vehicle; (4) APAP (400 mg/kg) + SolB (200 mg/kg). B and C, Serum ALT and AST activities (n = 6). *P < 0.05, **P < 0.01, and ***P < 0.001 compared with APAP group, #P < 0.05, ##P < 0.01, and ###P < 0.001 compared with vehicle.