Table 1.
Differentially expressed CRC metastasis-specific microRNAs between matched primary CRC and liver metastasis in NanoString analysis (nine pairs of frozen pCRC tissue and synchronous LM tissue)*
| Probe from NanoString | Geometric mean | Fold change (LM/pCRC) | FDR | P | |
|---|---|---|---|---|---|
| pCRC (n = 9) | LM (n = 9) | ||||
| hsa-miR-199b-5p | 360.77 | 70.81 | 0.2 | 0.01 | 6.E-05 |
| hsa-let-7i | 2154.94 | 1133.07 | 0.53 | 0.14 | 2.E-03 |
| hsa-miR-484 | 69.79 | 39.14 | 0.56 | 0.14 | 2.E-03 |
| hsa-miR-490-3p | 47.13 | 21.67 | 0.46 | 0.21 | 4.E-03 |
| hsa-miR-122 | 27.01 | 507.91 | 18.8 | 0.26 | 8.E-03 |
| hsa-miR-320a | 33.94 | 22.05 | 0.65 | 0.26 | 8.E-03 |
| hsa-miR-520e | 53.73 | 13.01 | 0.24 | 0.26 | 8.E-03 |
| hsa-miR-10b | 64.28 | 19.67 | 0.31 | 0.27 | 1.E-02 |
| hsa-miR-337-5p | 20.81 | 11.8 | 0.57 | 0.39 | 2.E-02 |
| hsa-miR-485-3p | 89.95 | 50.39 | 0.56 | 0.39 | 2.E-02 |
| hsa-miR-145 | 2915.38 | 1267.64 | 0.43 | 0.39 | 2.E-02 |
| hsa-miR-144 | 294.09 | 116.61 | 0.4 | 0.39 | 2.E-02 |
| hsa-miR-25 | 688.42 | 405.21 | 0.59 | 0.39 | 3.E-02 |
| hsa-miR-221 | 294.27 | 209.8 | 0.71 | 0.39 | 3.E-02 |
| hsa-miR-216a | 59.45 | 34.54 | 0.58 | 0.39 | 3.E-02 |
| hsa-miR-92b | 44.38 | 32.31 | 0.73 | 0.39 | 3.E-02 |
| hsa-miR-365 | 56.55 | 29.25 | 0.52 | 0.39 | 3.E-02 |
| hsa-miR-708 | 269.88 | 155.4 | 0.58 | 0.39 | 3.E-02 |
| hsa-miR-143 | 2652.88 | 1338.82 | 0.5 | 0.39 | 3.E-02 |
| hsa-miR-196a | 112.84 | 45.6 | 0.4 | 0.42 | 4.E-02 |
| hsa-miR-451 | 2174.72 | 623.91 | 0.29 | 0.46 | 4.E-02 |
| hsa-miR-30b | 1092.95 | 1864.19 | 1.71 | 0.46 | 5.E-02 |
| hsa-miR-885-5p | 24.46 | 64.95 | 2.65 | 0.46 | 5.E-02 |
* P values are paired t tests on the log2-transformed values of the NanoString expression data. FDR, Benjamini, and Hochberg False discovery rate based on the 219 miRNAs that passed the filtering criteria. CRC = colorectal cancer; FDR = false discovery rate; LM = liver metastasis; pCRC = primary CRC.