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. 2015 Feb 18;11(2):e1004996. doi: 10.1371/journal.pgen.1004996

Fig 1. Age-DMRs are mostly enriched for CGIs and the enrichment of age-hypermethylated CGIs increases after adjustment for changes in blood cell subtype composition.

Fig 1

A) Probabilities that a randomly picked open-sea, shore/shelf and CpG-island region is an age-DMR (defined as the top 5% of DMRs). B) Relative numbers of age-hypermethylated and age-hypomethylated DMRs within each regional class. C) Focusing on CpG-islands, density plots of beta DNAm values of 2500 age-DMRs (red) vs. 2500 non-age associated DMRs (green) (P > 0.8). D) As A) but now for age-DMRs derived using the reference-based method of Houseman et al, which adjusts for putative changes in blood cell subtype proportions. E) As B), but now for the adjusted analysis. F) Scatterplot of the t-statistics of age-DMRs (defined here as those with FDR < 0.05 in the unadjusted analysis) (x-axis) against their corresponding t-statistics from the reference-based adjusted analysis (t(RefBased), y-axis). Green dashed lines indicate the lines of significance at FDR < 0.05.