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. 2015 Feb 18;11(2):e1004996. doi: 10.1371/journal.pgen.1004996

Fig 3. Age-associated hypomethylated blocks exhibit preferential hypomethylation in cancer.

Fig 3

Left boxplots show the average beta methylation levels over open-sea regions within an age-associated hypomethylated block on Chr-10 in normal tissue and age-matched cancers from the TCGA. (A) Endometrial Cancer (UCEC), B) Lung Adenoma Carcinoma (LUAD), C) Breast Cancer, D) Lung Squamous Cell Carcinoma (LSCC). P-values in boxplots are from a Wilcoxon rank sum test. Number of samples in each group is indicated. Right panel depicts the density distribution of the t-statistics of all age-hypomethylated blocks (magenta), as assessed between normal and age-matched cancer tissue. The cyan curve represents the corresponding statistics for a random set of non-age associated blocks, matched for number and length distribution of the observed age-hypomethylated blocks. P-value is from a Kolmogorov-Smirnov test.