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. 2015 Feb 18;11(2):e1004996. doi: 10.1371/journal.pgen.1004996

Fig 5. Identification of pluripotent and lineage-specific TFs by integration of Illumina 450k DNAm with ENCODE data.

Fig 5

A) Probabilities that a randomly picked open-sea, shore/shelf and CpG-island region is a DMR between pluripotent and differentiated cells (defined as the top 5% of DMRs). B) Relative numbers of DMRs hypomethylated within hESCs and differentiated cell types and within each regional class. C) Enrichment heatmap of transcription factor binding sites (as assessed in H1-hESC) for 58 TFs, among the DMRs hypomethylated in hESCs (HypoESC) and DMRs hypomethylated in differentiated cells (HypoDIFF). D) Enrichment heatmap of transcription factor binding sites (HepG2 line) for the top ranked 58 TFs, among DMRs hypomethylated in hESCs (HypoESC) and DMRs hypomethylated in liver cells (HypoLIV). In C-D), TFs have been ranked according to the significance of enrichment among HypoESC DMRs. Color codes: white (P > 0.01), pink (P < 0.01), red (P < 1e − 5), brown (P < 1e − 10). ChIP-Seq binding profiles of the same TF but generated by different labs are distinguished by an abbreviation of the corresponding lab: SF (Stanford), HA (Hudson-Alpha).