Table 6.
Amino acid interactions within 3 Å distance from the compound.
| Compound | Amino acid interaction | ||||||
|---|---|---|---|---|---|---|---|
| 1 | Ser 342 | Glu 343 | Gly 344 | Arg 288 | Cys 285 | Met 348 | Ile 341 |
| ∗ | ∗ | — | — | — | — | — | |
|
| |||||||
| 3 | His 449 | Tyr 327 | Cys 285 | Ile 281 | Val 339 | Met 348 | His 323 |
| ∗ | — | — | — | — | — | — | |
|
| |||||||
| 4 | Pro 269 | Ser 342 | Thr 268 | Gly 264 | Cys 285 | Phe 287 | Leu 270 |
| — | ∗ | — | — | — | — | — | |
|
| |||||||
| 5 | Met 288 | Ile 281 | Cys 285 | Gly 284 | Arg 288 | Val 339 | Leu 340 |
| ∗ | — | — | — | — | — | — | |
|
| |||||||
| 6 | Ser 342 | Glu 343 | Gly 344 | Leu 340 | Cys 285 | Gly 284 | Met 348 |
| ∗ | ∗ | — | — | — | — | — | |
|
| |||||||
| Rosiglitazone | Glu 343 | Ser 342 | Cys 285 | Gly 284 | Ser 289 | Gly 344 | Ala 292 |
| — | ∗ | — | — | ∗ | — | — | |
— means absence of interaction; ∗ means interaction.