Table 3. Comparison of pharmacokinetic parameters of decursin (D), decursinol angelate (DA) and decursinol (DOH) in men vs. women receiving dietary supplement Cogni.Q orally.

PK parameter	Analyte	Men N = 10	Women N = 10	Unpaired t-test, 2-sided, p	post-hoc power
Tmax, h, Mean (SD)	D	1.7 (1.2)	2.4 (1.1)	0.192	72%
	DA	2.1 (1.6)	2.7 (1.1)	0.335
	DOH	2.4 (1.4)	4.1 (1.5)	0.014
Cmax, nmol/L, Mean (SD)	D	5.2 (5.1)	5.4 (4.9)	0.945
	DA	52.2 (73.0)	43.9 (41.3)	0.760
	DOH	2354 (950)	2606 (798)	0.529
			2208 DCMV*
AUC0–48h, h.nmol/L Mean (SD)	D	28.5 (20.8)	45.7 (34.7)	0.194
	DA	327.3 (466.5)	343.6 (341.6)	0.930
	DOH	22457 (8256)	32702 (16546)	0.097
			27713 DCMV*
T1/2, h, terminal Mean (SD) **	D	17.7 (7.8)	17.0 (6.2)	0.851	58%
	DA	14.9 (2.8)	23.7 (10.1)	0.044
	DOH	6.6 (1.9)	8.3 (1.7)	0.072

*Dose-corrected mean value: due to lighter body weight of women in the study, their actual dose of D/DA was 1.18x higher than men on per kg basis (See Table 1).

**The terminal half-life values for four subjects were considered as outliers and were excluded (See S1 Table).