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. 2015 Feb 19;10(2):e0117228. doi: 10.1371/journal.pone.0117228

Fig 4. Induction of tinnitus following SS alters the P2/P1 and P4/P1 amplitude ratios in response to 70 dB tone bursts.

Fig 4

(A) SS increased the P2/P1 amplitude ratio in response to all tone burst frequencies. (B) Each animal demonstrated a significant increase in the P2/P1 amplitude ratio for tinnitus frequencies (12, 16, & 20 kHz) following SS-induced tinnitus, confirming that the P2/P1 ratio is a sensitive measure of tinnitus. Dashed lines indicate the mean, mean + 1 standard deviation (SD), and the mean + 2 SDs for baseline testing. (C) SS-induced tinnitus also significantly affected the P4/P1 amplitude ratio; multiple comparisons analysis was significant for the increases in response to 16 and 20 kHz tones, while significantly decreased for 6 and 36 kHz responses (multiple comparisons test: **p <0.01, ***p<0.001, ****p<0.0001).