Table 4. Relative expression levels (2-ΔCT value) of drug efflux genes of nine MDR M. tuberculosis isolates and 10 pan-sensitive isolates.
| Gene | Pan-sensitive group | MDR group | ||
|---|---|---|---|---|
| Median value | 25%–75% value | Median value | 25%–75% value | |
| efpA a | 1.39 | 0.56–2.54 | 6.49 | 5.29–11.06 |
| emrB | 0.96 | 0.81–1.09 | 0.79 | 0.64–1.45 |
| Rv0849 a | 0.37 | 0.27–0.28 | 1.58 | 0.94–2.73 |
| Rv1250 a | 1.91 | 0.80–3.43 | 7.74 | 5.04–10.00 |
| tap (Rv1258c) | 0.76 | 0.65–1.39 | 1.15 | 0.41–1.34 |
| P55 (Rv1410c) a | 0.98 | 0.64–1.30 | 2.01 | 1.62–5.51 |
| Rv1634 b | 0.36 | 0.25–0.43 | 0.54 | 0.40–1.69 |
| Rv2994 a | 0.47 | 0.37–0.56 | 1.45 | 0.89–2.22 |
| Rv1877 b | 0.55 | 0.48–0.72 | 0.34 | 0.18–0.49 |
| stp a | 0.68 | 0.44–0.78 | 1.30 | 1.21–3.70 |
| jefA (Rv2459) a | 0.93 | 0.78–1.12 | 5.37 | 4.42–19.32 |
| Rv2265 a | 0.34 | 0.24–0.52 | 0.06 | 0.04–0.27 |
| Rv2456 | 0.48 | 0.32–0.68 | 0.21 | 0.14–0.53 |
| Rv3239 | 0.14 | 0.11–0.17 | 0.17 | 0.06–0.22 |
| mmpL13a b | 0.52 | 0.29–0.69 | 0.20 | 0.10–0.50 |
| mmpL13b | 0.17 | 0.13–0.23 | 0.20 | 0.16–0.41 |
| pstB a | 0.65 | 0.55–1.15 | 3.29 | 2.26–5.98 |
| drrA a | 3.52 | 1.54–5.24 | 9.46 | 6.06–15.22 |
| drrB a | 1.12 | 0.79–1.50 | 3.81 | 2.83–7.12 |
| mmr | 0.23 | 0.19–0.29 | 0.35 | 0.23–0.47 |
aSignificant differences between the MDR and pan-sensitive groups (P < 0.01)
bSignificant differences between the MDR and pan-sensitive groups (P < 0.05).