Fig 1. TRAMP^MIC-/- mice have shorter survival and larger prostate tumors than TRAMP^MIC+/+ mice.

(A) Survival data for TRAMP^MIC+/+ and TRAMP^MIC-/- mice (n = 35). Overall survival of individual mice from birth to death was plotted using the Kaplan-Meier method. The log-rank statistic for median survival time is shown. (B) The genitourinary complex (GU) and prostate tumor weights (C), in TRAMP^MIC+/+ and TRAMP^MIC-/- mice, at the necropsy, are corrected for body weight and presented as mean ± SEM. Differences are analyzed using an unpaired 2-tailed t test. (D) The number of TRAMP^MIC+/+ and TRAMP^MIC-/- mice having large prostate tumor (corrected tumor wt>10mg/g), was compared using a Chi-square test. p values are shown as *, p< 0.05; **, p< 0.01.