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. 2015 Feb 19;10(2):e0115636. doi: 10.1371/journal.pone.0115636

Fig 4. In vivo biodistribution of IONP.

Fig 4

Nanoparticles (80 μg/g body mass) were systemically administered by tail vein injection in NSG mice bearing BT-474 xenograft tumors. Iron content of various tissue compartments was quantified 24 hours post injection by ICP-MS. (A) Tumor, (B) Blood, (C) Heart, (D) Lung, (E) Liver, (F) Spleen, (G) Kidney. Statistical significance (P<0.05) was analyzed by one way ANOVA with a Tukey multiple comparison posttest. Solid brackets with asterisk indicate groups of mice that were not significantly different from each other but were significantly different from other groups outside the bracket. Significant differences between individual groups, including exceptions to the solid brackets, are indicated by solid arrows marked with an asterisk. For the heart, non-significance between individual groups (i.e. exceptions to the solid bracket) is indicated by hatched arrows marked with “ns”. For the heart, the 100 nm maleimide IONP group was not significantly different from any other group in the panel. N = 4 to 7 per group. Statistical analyses were completed using GraphPad Prism 5 (GraphPad Software, Inc., San Diego, CA).