Table 2.
Pooled dolutegravir mean changes from baseline of lipid serum levels from SPRING-1, SPRING-2, SINGLE, and FLAMINGO, and maximal post-baseline emergent grade 2–4 elevations
| Parameter | Baseline | Change from baseline to week 48 | Maximum post-baseline emergent grade 2–4 elevationsa | ||
|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | n/N (%) | |
| TC (mg/dL) | 953 | 160.5 (34) | 834 | 9.9 (27) | 78/1,118 (7) |
| LDL-C (mg/dL) | 946 | 94.1 (29) | 821 | 4.8 (21) | 65/1,118 (6) |
| Triglycerides (mg/dL) | 954 | 114.7 (71) | 836 | 8.7 (85) | 18/1,118 (2) |
| HDL-C (mg/dL) | 953 | 43.9 (13) | 834 | 3.6 (10) | NA |
| TC:HDL ratio | 1,013 | 3.9 (1) | 888 | −0.1 (1) | NA |
DAIDS Division of AIDS, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, NA not applicable, SD standard deviation, TC total cholesterol
aDAIDS grading system