Table 3.
Mean lipid changes from baseline to week 48 in the SPRING-2 study
| Parameter | Treatment | Baseline | Change from baseline | Maximum post-baseline emergent grade 2–4 elevationsa | ||
|---|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | n/N (%) | ||
| TC (mg/dL) | DTG | 356 | 163.8 (34) | 318 | 6.9 (28) | 32/411 (8) |
| RAL | 366 | 160.3 (38) | 308 | 9.0 (29) | 24/411 (6) | |
| LDL-C (mg/dL) | DTG | 354 | 96.8 (30) | 313 | 2.9 (21) | 29/411 (5) |
| RAL | 363 | 93.4 (32) | 302 | 3.3 (23) | 22/411 (5) | |
| HDL-C (mg/dL) | DTG | 356 | 44.4 (12) | 318 | 2.7 (11) | NA |
| RAL | 366 | 44.3 (13) | 308 | 2.7 (10) | NA | |
| TC:HDL ratio | DTG | 356 | 3.9 (1) | 318 | −0.04 (1) | NA |
| RAL | 366 | 3.8 (1) | 308 | −0.1 (2) | NA | |
| Triglycerides (mg/dL) | DTG | 357 | 113.8 (64) | 319 | 8.6 (91) | 7/411 (2) |
| RAL | 366 | 115.9 (82) | 308 | 10.1 (93) | 8/411 (2) | |
DAIDS Division of AIDS, DTG dolutegravir, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, NA not applicable, RAL raltegravir, SD standard deviation, TC total cholesterol
aDAIDS grading system