Table 1.

Classification of mutations found in hematological malignancies

Class I mutations (induce proliferation or inhibit apoptosis)

FLT3-ITD, cKit, PDGFR, TEL-PDGFR, FGFR

JAK2, JAK3, Bcr-Abl

N-Ras, K-Ras

p53, NF1

Class II mutations (inhibit differentiation or induce immortalization)

Runx 1/AML1, PU1, C/EBPα

MLL fusions, PML-RARα, AMΛ1–ETO