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. 2015 Feb 20;9:25. doi: 10.3389/fnbeh.2015.00025

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Copyright © 2015 Hertz, Rothman, Li and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of EGF receptors and of ERK is required for up-regulation of mRNA expression of c-fos and fosB by fluoxetine in astrocytes. Cells were incubated for 60 min in serum-free medium in the absence of any drug (Control) or in the presence of 10 μM fluoxetine alone or together with 1 μM AG 1478 or 10 μM U0126. Average mRNA expression (n = 3) was quantitated as ratios between c-fos and TBP, used as a house-keeping gene (A) and between fosB and TBP (B). SEM values are indicated by vertical bars. *Indicates statistically significant (P < 0.05) difference from Control, AG 1478, fluoxetine plus AG 1478, U0126, and fluoxetine plus U0126 groups for c-fos and fosB. (Li et al., 2008a).