Table 1.

Selected genes with expression changes passing the filter of fold change >2.0 and FDR <0.05 in at least one time point for Fasudil-treated compared with untreated astrocytes.

Probeset ID	Definition	2 h		6 h		12 h		24 h
		P-value	Fold-change	P-value	Fold-change	P-value	Fold-change	P-value	Fold-change
KIF2A	Kinesin family member 2A	8.89E-03	−1.48	1.34E-07	−2.89	1.89E-01	1.20	8.36E-01	−1.03
RAB3D	Member RAS oncogene family	8.14E-02	1.23	7.50E-03	1.40	1.76E-07	−2.37	1.55E-05	−1.88
DRP2	Dystrophin related protein 2	2.06E-02	1.53	5.92E-01	1.10	5.41E-05	−2.35	4.62E-03	−1.71
FOXO1	Forkhead box O1	1.99E-09	−4.19	2.62E-05	−2.16	1.96E-04	1.91	4.26E-02	1.36
SQSTM1	Sequestosome 1	1.43E-03	−1.36	8.35E-09	−2.17	1.04E-02	1.27	2.03E-04	1.46
MFN1	Mitofusin 1	4.32E-01	1.17	7.11E-06	−3.20	3.32E-01	−1.22	2.61E-01	1.26
JAK2	Janus kinase 2	3.59E-02	−1.34	1.29E-05	−2.10	2.78E-01	1.16	2.71E-01	1.16
NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1.24E-06	−1.85	1.33E-03	1.40	2.26E-03	1.37	2.67E-01	1.11
SOCS3	Suppressor of cytokine signaling 3	4.67E-08	−5.41	5.77E-02	−1.51	3.87E-01	1.20	4.94E-01	−1.15
HIF1A	Hypoxia inducible factor 1, alpha subunit	6.84E-01	1.07746	3.97E-02	−1.486	1.39E-01	1.32015	4.31E-01	1.15591
VEGFA	Vascular endothelial growth factor A	6.18E-06	−3.49	8.83E-02	−1.45	2.28E-01	1.30	5.78E-01	1.13
HK2	Hexokinase 2	4.25E-07	−4.96	2.95E-05	−3.25	3.48E-01	−1.24	1.92E-01	−1.35

Gene expression data are from NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE25829 (Lau et al., 2012). The FDR threshold of 0.05 corresponds to a P-value of 5.2 × 10⁻³, 01.47 × 10⁻², 5.55 × 10⁻³ and 1.72 × 10⁻³ for the 2, 6, 12, and 24 h time points, respectively. P-value passing the FDR threshold at each time point are italicized.