FIGURE 3.

Whole-cell patch clamp recordings were performed on synthetic VSMCs that were infected with lentiviruses encoding either control shNT or shLTC₄S. Silencing of LTC₄S did not affect LRC currents in VSMCs activated by direct dialysis with 100 nm LTC₄ through the patch pipette (D; compare with shNT control in A). LRC Ca²⁺ and Na⁺ I/V relationships for both conditions are shown in B and E, respectively. Statistics on LRC Ca²⁺ and Na⁺ current densities are shown in C and F, respectively. Error bars represent S.E. I/V curves were taken where indicated by the + and * symbols. pF, picofarad.