FIGURE 6.

Congo red histological staining of the amyloid burden in 15-month-old double-transgenic tgHpa*Swe and single-transgenic tgSwe mice. A, plaques and CAA in a tgSwe mouse. The arrowhead indicates CAA, and the arrow indicates plaque. Scale bar = 200 μm. Quantitative image analysis showed that total cortical amyloid (CAA plus plaque area) (B) as well as the CAA burden (C) was lower in double-transgenic tgHpa*Swe mice (n = 17) than in single-transgenic tgSwe mice (n = 17). The percentage of CAA of the total amyloid burden in the cerebral cortex showed no difference between single- and double-transgenic mice (D). Lines indicate medians with interquartile range.