Skip to main content
. 2014 Dec 30;290(8):5065–5077. doi: 10.1074/jbc.M114.603217

FIGURE 1.

FIGURE 1.

NLRP3−/− mice are susceptible to oxygen-induced lethality. A, survival of WT and NLRP3−/− mice exposed to hyperoxia was analyzed using the Kaplan-Meier method (n = 18–19 for each). B, survival of WT and IL-1β−/− mice exposed to hyperoxia was analyzed using the Kaplan-Meier method (n = 9–12 for each). C, IL-1β levels were assessed in the BALF of WT and NLRP3−/− mice exposed to normoxia or hyperoxia for 72 h (n = 3–5 for each in normoxia, and n = 12–14 for each in hyperoxia). D, Il1b mRNA levels were assessed in the lung tissue of WT and NLRP3−/− mice exposed to normoxia or hyperoxia for 72 h (n = 6 for each in normoxia, and n = 9–12 for each in hyperoxia). Data are expressed as the means ± S.E. **, p < 0.01.