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Superpositions of chains A of the 3TBG structure representative of the crystals before incubation (gray carbons), the 3TDA structure of prinomastat complex obtained after incubation of the crystals with prinomastat (amber carbons), and the 3QM4 structure obtained earlier for crystals of P450 2D6 co-crystallized with prinomastat (cyan carbons) are depicted in two views of the active site region. Other atoms are colored as described in the legend for Fig. 2.
