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. 2014 Nov 7;4(11):259. doi: 10.1038/bcj.2014.78

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Supervised analyses identified (a) differentially expressed miRNAs between PTCL/NOS and activated CD4+ and CD8+ T-lymphocytes. miRNAs with differences in expression were selected by the comparative cycling threshold methods (ΔΔCT) and filtered for statistical significance (two-tailed Student's t-test P-value <0.05 and FC >2). (b) Genes differentially expressed between PTCL/NOS and activated CD4+ and CD8+T-lymphocytes (t-test, P-value <0.05, FC >2, false discovery rate (FDR) adjusted Bonferroni correction). Top 500 genes in ranking are plotted. In the matrix, each row represents an miRNA/gene and each column represents a sample. The colour scale illustrates the relative expression level of an miRNA and genes across all samples: red represents an expression level above the mean and green represents expression lower than the mean. (c) Bioinformatic approach (three steps). Schematic representation of miRNA profiling and gene expression profiling data integration. The flow diagram is constituted by three steps indicated in the figure by three arrows.