. 2015 Jan 5;22(2):121–130. doi: 10.1530/ERC-14-0537
This work is licensed under a Table 2.
Demographic and clinical characteristics of TCGA THCA samples based on SDHx gene expression differences
| Gene_scorea | 0 | 1 | 2 | 3 | 4 | P valueb |
|---|---|---|---|---|---|---|
| Mean of age_at_diagnosis (n) | 44.98 (n=245) | 47.37 (n=104) | 50.14 (n=63) | 50.60 (n=25) | 52.93 (n=29) | 0.015 |
| Gender | ||||||
| Female (n=343) | 178 | 77 | 45 | 20 | 23 | 0.867 |
| Male (n=123) | 67 | 27 | 18 | 5 | 6 | |
| Pathology_T | ||||||
| T1 (n=135) | 75 (55.6%) | 22 (16.3%) | 22 (16.3%) | 7 (5.2%) | 9 (6.7%) | 0.051 |
| T2 (n=154) | 83 (53.9%) | 38 (24.7%) | 15 (9.7%) | 3 (1.9%) | 15 (9.7%) | |
| T3 (n=156) | 76 (48.7%) | 40 (25.6%) | 22 (14.1%) | 14 (9%) | 4 (2.6%) | |
| T4 (n=19) | 9 (47.4%) | 4 (21.1%) | 4 (21.1%) | 1 (5.3%) | 1 (5.3%) | |
| Pathology_N | ||||||
| N0 (n=213) | 106 (49.8%) | 38 (17.8%) | 38 (17.8%) | 16 (7.5%) | 15 (7.0%) | <0.001 |
| N1 (n=207) | 119 (57.5%) | 57 (27.5%) | 19 (9.2%) | 7 (3.4%) | 5 (2.4%) | |
| NX (n=46) | 20 (43.5%) | 9 (19.6%) | 6 (13.0%) | 2 (4.3%) | 9 (19.6%) | |
| Pathology_M | ||||||
| M0 (n=252) | 147 (58.3%) | 51 (20.2%) | 39 (15.5%) | 10 (4.0%) | 5 (2.0%) | <0.001 |
| M1 (n=8) | 8 (100%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
| MX (n=205) | 90 (43.9%) | 53 (25.9%) | 24 (11.7%) | 14 (6.8%) | 24 (11.7%) | |
| NA (n=1) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) | 0 (0%) | |
| Pathology_stage | ||||||
| Stage I (n=264) | 145 (54.9%) | 59 (22.3%) | 37 (14.0%) | 10 (3.8%) | 13 (4.9%) | 0.002 |
| Stage II (n=0) | 0 | 0 | 0 | 0 | 0 | |
| Stage III (n=104) | 50 (48.1%) | 29 (27.9%) | 13 (11.5%) | 11 (10.6%) | 2 (1.9%) | |
| Stage IV (n=7) | 6 (85.7%) | 1 (14.3%) | 0 (0%) | 0 (0%) | 0 (0%) | |
| NA (n=91) | 44 (48.4%) | 15 (16.5%) | 14 (15.4%) | 4 (4.4%) | 14 (15.4%) | |
| Histology | ||||||
| Classic PTC (n=321) | 189 (58.9%) | 73 (22.7%) | 38 (11.8%) | 11 (3.4%) | 10 (3.1%) | <0.001 |
| FvPTC (n=99) | 36 (36.4%) | 17 (17.2%) | 16 (16.2%) | 12 (12.1%) | 18 (18.2%) | |
| TallCell PTC (n=35) | 14 (40.0%) | 12 (34.3%) | 8 (22.9%) | 1 (2.9%) | 0 (0%) | |
| Others (n=11) | 6 (54.5%) | 2 (18.2%) | 1 (9.1%) | 1 (9.1%) | 1 (9.1%) |
a
Gene_score (range from 0 to 4) was calculated by first categorizing each gene's expression as either 1 as higher than normal, or 0 as lower than normal, then adding up the binary score for each of these SDHA–D genes.
b
P value was calculated by one-way ANOVA for age_at_diagnosis with degree of freedom of 4, and by Pearson χ2 test for the rest of comparisons.