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. 2015 Feb 15;29(4):379–393. doi: 10.1101/gad.254425.114

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© 2015 Liu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — The H3K9 methylation-binding activity of GLP was required for mouse viability and calvaria ossification. (A) Mouse counts revealed the postnatal lethality of GLP^M/M mice. (B) Growth retardation of GLP^M/M mice at birth. Error bars represent the standard error. (C) Newborn mice of GLP and G9a single and double mutants. (D,E) Suckling assays showing the abilities of newborn mice to search and lick nipples (D) and remain stably attached to the nipples (E). (F) Alizarin red staining of neonatal mouse calvaria showing delayed ossification at the nasal bones and sagittal (arrowhead) and metopic (arrow) structures in GLP^M/M mice. (G) MicroCT scanning showing bone loss in metopic sutures (arrow) of an adult GLP^M/M mouse that survived.