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. Author manuscript; available in PMC: 2015 May 6.
Published in final edited form as: N Engl J Med. 2014 Nov 6;371(19):1793–1802. doi: 10.1056/NEJMoa1312547

Table 1.

Life-Years and Quality-Adjusted Life-Years per Person.*

Time Horizon Life Expectancy Quality-Adjusted Life Expectancy
CT Radiography CT Radiography
life-yr QALY
Within trial 5.7846 5.7775 4.3390 4.3351

  Participants with lung cancer 4.9013 4.6029 3.5603 3.3596

  Participants without lung cancer 5.8228 5.8228 4.3728 4.3728

Lifetime 14.7386 14.7071 10.9692 10.9491

  Participants with lung cancer 8.4792 6.8479 6.0521 4.8981

  Participants without lung cancer 15.0097 15.0103 11.1821 11.1825
*

Life-years were discounted at 3% and are defined as follows: within-trial life-years were calculated from the date of randomization to the date of death if the patient was deceased; to December 31, 2009, if the patient was alive; or to the latest date on which the patient was known to be alive if data on vital status were missing on December 31, 2009. For participants not known to be deceased by that date, beyond-trial life-years were estimated on the basis of the participants’ age on the date they were last known to be alive, sex, smoking status at study entry, and lung-cancer stage, if any, with the use of 2009 U.S. Life Tables18 adjusted for smoking status and stage-specific annual probabilities of dying from lung cancer. For further details see Sections 3 and 4 in the Supplementary Appendix. The results for participants who underwent no screening were assumed to be the same as for those who underwent radiographic screening.

For participants without lung cancer, outcomes were assumed to be the same for those who underwent CT screening and those receiving radiographic screening except for an adjustment for the occurrence of radiation-induced lung cancer after the trial.