Table 2.

Plasma lipid and lipoprotein changes upon alteration in the expression of the LIGHT/lymphotoxin co-stimulatory family in female Ldlr^−/− mice fed a western-type diet for 12 weeks. All differences are relative to control Ldlr^−/− mice.

LIGHT/Lymphotoxin family models	Site of expression/deficiency	Plasma lipid effects	Lipoprotein effects
Transgene
LIGHT	T cell	↑	↑ HDL1
Deficiency
LIGHT	Global	↓	↓ VLDL, LDL, HDL
Ltα	Global	↓	↓ VLDL, LDL
Ltβ	T cell	↓	↓ VLDL, LDL
HVEM	Global	↓	↓ VLDL, LDL, HDL
LTβR	Global	–

HDL: High-density lipoprotein; HVEM: Herpes virus entry mediator; LDL: Low-density lipoprotein; Ldlr^−/−: LDL receptor deficient; Lt: Lymphotoxin; LTβR: Lymphotoxin β receptor; VLDL: Very low density lipoprotein.

Data from [A Reardon & GS Getz, Unpublished Data].