Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Apr 10;1:8. doi: 10.3389/fmed.2014.00008

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Chaudhury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Shank proteins are widely distributed in nature in both prokaryotes and eukaryotes. Left panel shows protein association of shank3 across animal and plant kingdom. The interactive analyses were performed using STRING 9.1 software (71). Right panel shows protein-association partners of mouse shank3 (performed with STRING9.1) and human shank2 (performed with STITCH3.1) (72). Protein interaction partners reveal components of both postsynaptic (inotropic glutamate receptor GRID2, homer, GKAP, PSD, neuroligin) as well as presynaptic compartments (latrophilin, dynamin). Note that scaffolding proteins like PSD95 are not restricted to the postsynaptic compartment but are present presynaptically in enteric nerve varicosities. Note that shank3 and shank2, proteins that are both present in nitrergic myenteric neurons, have different binding partners. This may have an implication for distinct functions of shank3 and shank2 in nitrergic neurotransmission.