Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 20;1:17. doi: 10.3389/fmed.2014.00017

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Chaudhury, De Miranda-Neto, Pereira and Zanoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Details of myosin Va staining of ganglionic neurons and their processes in diabetic jejunum. Note the heterogeneity of appearance of myosin Va in the cell bodies of the neurons in the myenteric plexus. In the left panel, note the moderate staining in the cell bodies of many neurons. Also note that the secondary plexus running to the left of the image has some brown DAB staining. Some of the neuromuscular varicosities have faint brown staining. In the middle panel, note the enlarged neuronal soma with unhealthy appearing nucleus, possibly indicating a degenerating neuronal cell body. The increase in size may be related to the cellular accumulation of myosin Va, possibly resulting from stasis of myosin Va axonal transport. Also note the absence of brown staining in all of the neuronal processes ramifying through the muscular wall. The right panel recapitulates information represented in the middle panel and in addition, shows a full range of neuronal cytopathology. Note that in the upper pole, two neurons do not have any cytoplasmic staining and the lower neuron is possible degenerative, as evidenced by unusual nuclear appearance. Note very scant or nearly absent staining in the interneuronal processes, secondary plexi as well as tertiary neuromuscular nerve varicosities. Also note that some cells (top right, also one cell body in the right on left panel) show intense dark brown staining. This heterogeneous appearance may result from enhanced myosin Va transcription but may have also resulted from myosin Va aggresome formation. Scale bar, 25 μm.