Table 3.
Association of staphylococcal carriage with microbial communities at carriage sites at the baseline visit
| Comparison category | Host species | Anatomic site | Beta diversity metric | R statistic and significance |
|---|---|---|---|---|
| CPS colonization status (Yes or no) | Humans | Nares | Weighted UniFrac | 0.008 |
| Unweighted UniFrac | 0.0389 | |||
| Bray-Curtis | −0.0165 | |||
| Binary Jaccard | 0.0113 | |||
| Humans | Inguinal/axilla | Weighted UniFrac | 0.1514 | |
| Unweighted UniFrac | 0.1391 | |||
| Bray-Curtis | 0.2577 | |||
| Binary Jaccard | 0.1983 | |||
| Cats | Nares | Weighted UniFrac | −0.0729 | |
| Unweighted UniFrac | −0.0683 | |||
| Bray-Curtis | −0.0626 | |||
| Binary Jaccard | −0.0459 | |||
| Cats | Oral cavity | Weighted UniFrac | −0.0356 | |
| Unweighted UniFrac | −0.0347 | |||
| Bray-Curtis | −0.0717 | |||
| Binary Jaccard | −0.0480 | |||
| Dogs | Nares | Weighted UniFrac | 0.0994 | |
| Unweighted UniFrac | 0.0369 | |||
| Bray-Curtis | 0.1299 | |||
| Binary Jaccard | 0.1483 | |||
| Dogs | Oral cavity | Weighted UniFrac | 0.1491 | |
| Unweighted UniFrac | 0.2495* | |||
| Bray-Curtis | 0.1265 | |||
| Binary Jaccard | 0.1751 | |||
| S. aureus colonization status (Yes or no) | Humans | Nares | Weighted UniFrac | −0.0063 |
| Unweighted UniFrac | −0.0938 | |||
| Bray-Curtis | −0.0845 | |||
| Binary Jaccard | −0.1714 | |||
| Humans | Inguinal/axilla | Weighted UniFrac | No S. aureus at this time point | |
| Unweighted UniFrac | ||||
| Bray-Curtis | ||||
| Binary Jaccard | ||||
| Cats | Nares | Weighted UniFrac | −0.0228 | |
| Unweighted UniFrac | −0.1451 | |||
| Bray-Curtis | −0.1280 | |||
| Binary Jaccard | −0.0980 | |||
| Cats | Oral cavity | Weighted UniFrac | −0.2021 | |
| Unweighted UniFrac | −0.1815 | |||
| Bray-Curtis | −0.220 | |||
| Binary Jaccard | −0.1398 | |||
| Dogs | Nares | Weighted UniFrac | −0.0540 | |
| Unweighted UniFrac | −0.1028 | |||
| Bray-Curtis | −0.1452 | |||
| Binary Jaccard | −0.2037 | |||
| Dogs | Oral cavity | Weighted UniFrac | −0.1012 | |
| Unweighted UniFrac | −0.1176 | |||
| Bray-Curtis | −0.1831 | |||
| Binary Jaccard | −0.0311 | |||
| MRSA colonization status (Yes or no) | Humans | Nares | Weighted UniFrac | −0.0236 |
| Unweighted UniFrac | −0.1443 | |||
| Bray-Curtis | −0.0718 | |||
| Binary Jaccard | −0.1910 | |||
| Humans | Inguinal/axilla | Weighted UniFrac | 0.1150 | |
| Unweighted UniFrac | −0.1172 | |||
| Bray-Curtis | 0.1653 | |||
| Binary Jaccard | 0.0008 | |||
| Cats | Nares | Weighted UniFrac | −0.2287 | |
| Unweighted UniFrac | −0.2056 | |||
| Bray-Curtis | −0.2460 | |||
| Binary Jaccard | −0.2810 | |||
| Cats | Oral cavity | Weighted UniFrac | −0.2582 | |
| Unweighted UniFrac | −0.0009 | |||
| Bray-Curtis | −0.2450 | |||
| Binary Jaccard | −0.0194 | |||
| Dogs | Nares | Weighted UniFrac | −0.2705 | |
| Unweighted UniFrac | −0.0066 | |||
| Bray-Curtis | −0.2904 | |||
| Binary Jaccard | −0.2473 | |||
| Dogs | Oral cavity | Weighted UniFrac | No MRSA at this time point | |
| Unweighted UniFrac | ||||
| Bray-Curtis | ||||
| Binary Jaccard |
Summarized are ANOSIM analyses assessing association of various metadata on microbial community distances measured using weighted and unweighted UniFrac, Bray-Curtis index, and Jaccard index. *p < 0.05 (FDR adjusted value).