Figure 6. Deletion of individual sod genes results in a compartment specific effect on sensitivity to oxidative stress in clk-1 worms.

A. Deletion of sod-1 or sod-2 increases clk-1 sensitivity to oxidative stress during development. B. Deletion of sod-1, sod-4 or sod-5 increases clk-1 sensitivity to oxidative stress after acute exposure to juglone on day 1 of adulthood. In contrast, deletion of either mitochondrial sod gene, sod-2 or sod-3, reverts stress sensitivity to wild-type. C. Deletion of sod-1, sod-2 or sod-5 increases clk-1 sensitivity to oxidative stress during chronic exposure to 4 mM paraquat beginning on day 1 of adulthood. Note that deletion of sod-1 and sod-2 both increase sensitivity to paraquat in clk-1 worms despite having opposite effects on lifespan. Significance indicates difference from clk-1 worms. Error bars indicate SEM. * p<0.05, ** p<0.01, *** p<0.001. FA = fertile adult.