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. 2015 Feb 11;11(2):e1004972. doi: 10.1371/journal.pgen.1004972

Figure 7. ROS-dependent and ROS-independent mechanisms contribute to longevity in clk-1 worms.

Figure 7

A. Treatment with three difference antioxidants (10 mM Vitamin C, 25 μM α-Lipoic acid or 25 μM epigallocatechin 3-gallate (EGCG) decreases clk-1 lifespan but does not revert it to wild-type. B. Treatment with paraquat increases clk-1 lifespan. The optimum paraquat concentration for clk-1 longevity is not decreased compared to wild-type worms. C,D. In contrast, paraquat treatment only decreases the lifespan of sod-2 worms and clk-1;sod-2 worms, both of which exhibit a decrease in their optimum paraquat concentration for longevity. Significance indicates difference from clk-1 worms. Error bars indicate SEM. *p<0.05, **p<0.01, ***p<0.001.