Table 2.
Comparison of exposures achieved in this study with other studies (mean (%CV))
| Anidulafungin | Caspofungin | Fluconazole | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | This study (ICU patients) | Liu et al. [25] (ICU patients) | Liu et al. [25] (healthy volunteers) | This study (ICU patients) | Wurthwein et al. [26] (general patients) | Stone et al. [27]a (healthy volunteers) | This study b (ICU patients) | Buijk et al. [23]a (surgical patients) | Sobue et al. [24]b (Healthy volunteers, 800 mg) |
| AUC 0–24 | 55 (28) | 93.0 (41) | 105.0 (22) | 52.0 (53) | 170.0 (34) | 97.0 (87–109) | 359 (259) | 409 (336–482) | 608 (118) |
| C max | 3.9 (29) | 7.7 (56) | 7.0 (22) | 3.9 (55) | 13.8 (31) | 12.1 (11–13) | 20 (14) | 25 (22–28) | 34 (6) |
| C min | 1.8 (30) | 3.0 (44) | 3.1 (25) | 1.5 (57) | 4.2 (2.56) | 1.4 (1.1–1.8) | 14 (11) | 15 (10–20) | 20 (NR) |
aMean (95% CI); bMean (SD). AUC0–24, area under the concentration-time curve from 0 to 24 hours Cmax, observed maximum concentration; Cmin, observed minimum concentration; CV, coefficient of variation; ICU, intensive care unit.