Table 3.
Comparison of IC 50 values determined using the Pf LDH assay in 2006 in the same population and the Sybr Green assays in 2012
| 2005-2007 | 2011-2013 | P -value | |||
|---|---|---|---|---|---|
| Drug | n | IC 50 | n | IC 50 | |
| Chloroquine | 63 | 167 (141–197) | 48 | 87 (71–106) | <0.001 |
| Piperaquine | 57 | 11.7 (10.2-13.4) | 47 | 21.1 (17–26) | <0.001 |
| Naphthoquine | 41 | 7.0 (5.5-8.8) | 44 | 4.2 (3.1-5.8) | 0.015 |
| Lumefantrine | 25 | 2.4 (1.8-3.1) | 47 | 1.5 (1.1-2.1) | 0.075 |
| Dihydroartemisinin | 30 | 2.1 (1.5-2.9) | 50 | 5.2 (4.2-6.5) | <0.001 |
Data are geometric mean and (95% CI) and P-values are two-tailed from Student’s t-test.